Mutation rate and survival with ICR-170
نویسندگان
چکیده
منابع مشابه
Induction of petite mutants in Saccharomyces cerevisiae by ICR-170 and their genetic characterization.
The strain employed was S288C, a genetically well-studied respiration-sufficient haploid that forms predominantly single cells and cells with one bud during log-phase growth and single cells in stationary phase. The respiratory genetic makeup of spontaneous and induced petites was determined by tetrad analysis and by complementation tests (PITTMAN et al. 1960; SHERMAN and EPHRUSSI 1962) using s...
متن کاملDNA sequences of frameshift and other mutations induced by ICR-170 in yeast.
ICR-170-induced mutations in the CYC1 gene of the yeast Saccharomyces cerevisiae were investigated by genetic and DNA sequence analyses. Genetic analysis of 33 cyc1 mutations induced by ICR-170 and sequence analysis of eight representatives demonstrated that over one-third were frameshift mutations that occurred at one site corresponding to amino acid positions 29-30, whereas the remaining muta...
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MONOFUNCTIONAL quinacrine mustard, 2-methoxy-6-chloro-9(3[ethyl2-chloroethyl] aminopropylamino) acridine dihydrochloride, ICR-170*, consists of two portions: an acridine ring and an alkylating mustard. The complex chemical structure of PCR-170 suggests that mutations could be produced by several different mechanisms. If the nitrogen mustard component of the molecule is the effective part of the...
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ژورنال
عنوان ژورنال: Fungal Genetics Reports
سال: 1969
ISSN: 1941-4765
DOI: 10.4148/1941-4765.2038